Does Your Gut Supplement Cover the Whole Tract?
Most gut supplements focus on the stomach or the hindgut. Not both. Four Sixes Complete Gut Protection is built to support the entire digestive tract.
A Stressed Gut Starts a Fire
The gut is two systems. A foregut and a hindgut. Both break down under stress.
Training, hauling, feed changes, and hard feed all push the gut past what it was built to handle. Acid splashes where it does not belong. Starch spills into the hindgut. The good microbes die off and the bad ones take over.
- Acid erodes the unprotected stomach lining
- Bad bacteria drop the pH and crowd out the good
- The gut wall weakens and toxins leak into the bloodstream
This is leaky gut, but it does not stay in the gut. Those toxins travel to the muscles, the joints, and the whole body. Four Sixes Complete Gut Protection is the only supplement built to defend both ends of the tract at once.
You Are Protecting Half of the Gut.
Most gut supplements pick a side. A buffer for the stomach. A probiotic for the hindgut. One or the other. But the gut is two systems working as one. A kitchen up front and a brewery in the back. When one suffers, the other is listening. Complete Gut Protection is the only supplement built to defend both ends of the tract at the same time.
Pre. Pro. Post. The Complete Trifecta.
Most gut supplements pick one. Complete Gut Protection runs all three.
01
Prebiotic: The Fertilizer
Prebiotics feed the good microbes and act as decoys for the bad ones. The bad bacteria latch on and get flushed out in the manure. Fuel for the good, a trap for the bad.
02
Probiotic: The Reinforcements
Not a random tincture of strains. Acid-resistant probiotics that survive the gut, suppress the bad microbes, and let the horse's own trillions of good microbes expand back to balance.
03
Postbiotic: The Finished Tools
Postbiotics are the beneficial molecules microbes produce. Fed at research-backed levels, they cross into the bloodstream and calm inflammation far beyond the gut. In studies, adding the postbiotic alone lowered inflammation inside the joint.
04
L-Glutamine: The Fuel for the Lining
The trifecta handles the hindgut. L-Glutamine feeds and protects the stomach and small intestine lining. That is how one supplement covers the whole tract, end to end.
What You Are Feeding Matters
Not all gut supplements are created equal.
| What to look for | Four Sixes Equine Supplements | The Other Guys |
|---|---|---|
| Formulated by board-certified equine veterinarians and PhD equine nutritionists | ✓ | ✗ |
| Supports the foregut and hindgut in one formula | ✓ | ✗ |
| Complete pre, pro, and postbiotic stack | ✓ | ✗ |
| Research-backed ingredients | ✓ | Rarely |
| Vet-level dosages | ✓ | Often underdosed |
| Competition safe - all ingredients | ✓ | Varies |
| Used on the Four Sixes ranch and trusted in the arena | ✓ | ✗ |
Ranch Developed
Built for the 6666's own working horses.
PhD-Backed
Research-based formulas. No fluff.
Vet-Formulated
Formulated by board-certified equine veterinarians.
Early Signs of Gut Issues
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Poor Recovery
Slow to bounce back after work. Times slip and you cannot figure out why.
Slow to bounce back after work. Times slip and you cannot figure out why.
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Weight Loss
Drops condition even on good feed. The nutrients are passing through, not absorbing.
Drops condition even on good feed. The nutrients are passing through, not absorbing.
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Dull Coat
Loses the shine and looks rough. When the gut struggles, it shows in the coat.
Loses the shine and looks rough. When the gut struggles, it shows in the coat.
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Behavioral Changes
Pins the ears or flinches when the girth tightens. Often the first sign of a stomach ulcer.
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Loose Manure
Chronic loose or watery manure that will not firm up.
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Poor Appetite
Leaves grain, eats slower, or walks away from the feed tub. The gut is telling you something.
Gut Testimonials
Tina L.
Had a barrel mare that got cinchy and started leaving feed. Vet found ulcers. We treated her, but they kept coming back every time we hit the road hard. Put her on Complete Gut Protection and kept her on it through haul season. No more cinchy, nice manure, and she is finishing runs strong again.
Debra Jo M.
I started using the gut supplement because my gilding has water fecal syndrome, and I have tried everything possible to treat it. The gut supplement is the only thing that has helped him. I have taken him off alfalfa and orchard hay as well. I believe this product is the only supplement that has consistently helped balance his gut and given him relief.
Amber West
Great product that keeps all of our performance horses working at their best
William C.
My gelding was on omeprazole for months and the second we pulled him off, everything came right back. Our vet suggested we add a gut supplement that covers both ends. Switched to this and weaned him off the meds. He has held steady for six months now. Wish I had found it sooner.
Tami L.
We start every horse in training on this now. Between the hauling, the hard feed, and the show schedule, they are all in the crosshairs for ulcers. Getting ahead of it has saved us money and vet visits. Feed it before you have a problem.
Horses That Depend on Four Sixes Gut
Is your horse at risk for ulcers?
Answer a few questions to see where your horse stands and what to do about it.
How many days a week is your horse in heavy work?
How much grain or concentrated freed does your horse get daily?
How often does your horse haul or travel?
How much of the day does your horse spend in a stall?
Is your horse on but or other pain medication regularly?
Are you seeing any of these signs already? Cinchy behavior, loose manure, leaving feed, dull coat, poor recovery, weight loss?
Your Score: out of
Frequently Asked Questions
How is Four Sixes Complete Gut Protection different from other gut supplements?
Why does it have prebiotics, probiotics, and postbiotics?
What is the difference between the foregut and the hindgut?
Why does the gut affect the whole horse?
When should I start gut support?
Education
Explore educational content and insights from our veterinary team, ambassadors, and the ranch.
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The Trade-Off: What Common Medications Like Bute, Lasix, and Omeprazole Are Actually Doing to Your Horse's Gut
July 08, 2026 -
What It Takes to Run an Elite Stallion Program: Inside the Four Sixes
From the January prep to the final collection of the year, the demands on a Four Sixes stallion never stop. Here is an inside look...
June 16, 2026 -
When the Treatment Ends: Why Ulcers Come Back After Omeprazole and How to Stop It
Stopping omeprazole is not the finish line. Here is what happens to your horse's stomach after treatment ends and what you can do about it.
May 13, 2026 -
Building It to Last: Britta Strain’s Program, Golden Cloud, and the Mares Behind It
Britta Strain is building more than a winning horse. She is building a program that lasts. Here is an inside look at the mares, the...
May 01, 2026 -
What Does a Lame Horse Feel Like?
What does it mean when a horse is lame and what does it feel like? Click here for the telltale signs of a lame horse...
January 23, 2024 -
Joint Injections vs. Joint Supplements: What Your Vet Wants You to Know
Joint injections and supplements do not do the same job. Here's what each one actually does, what most programs miss, and how to build a...
April 02, 2026 -
Does your horse have a leaky gut?
When the gut breaks down, everything follows. Here's what leaky gut actually is, what causes it in performance horses, and how to support the barrier...
March 26, 2026 -
Hindgut Ulcers: What Most Horse Owners Miss
Hindgut ulcers are common in performance horses, but they’re often overlooked. Understanding how routine stressors affect the hindgut helps explain why digestion, hydration, and overall...
January 09, 2026 -
Here's to the Great Horses: Meet Cornbread
Heavens Got Credit, aka Cornbread, owned by 6666 Equine Supplements ambassador and professional barrel racer Mindy Holloway, entered the 2025 National Finals Rodeo prepared for...
December 18, 2025 -
When the Temperature Drops, Joints Feel It First
Cold weather and hauling can make joint stiffness more noticeable in horses. Learn how gut health supports soundness year-round.
December 16, 2025 -
Immune Health in Horses: How the Gut Sets the Pace
December 02, 2025 -
The 5 Most Common Horse Hydration Myths Debunked
August 18, 2025